HBeAg negative chronic hepatitis B in South Asia

Authors

  • Ananta Shrestha Liver Foundation, Nepal.
  • Thupten Kelsang Lama Department of Medicine, Hepatology wing, Civil Service hospital, Nepal.
  • Sudhamshu KC Department of Hepatology, NAMS, Bir Hospital, Nepal.
  • Dilip Sharma Department of Hepatology, NAMS, Bir Hospital, Nepal.
  • Sandip Khadka Department of Hepatology, NAMS, Bir Hospital, Nepal.
  • Guru Prasad Dhakal Department of Medicine, Jigme Dorji Wangchuck National Referral Hospital, Bhutan.
  • Birendra Prasad Gupta Central Department of Biotechnology, Tribhuvan University, Nepal.

DOI:

https://doi.org/10.47811/YVJF8639

Abstract

Chronic Hepatitis B (CHB) infection has an intermediate prevalence rate in South Asian countries, except for Nepal and Sri Lanka
where it has a low rate. HBeAg negative CHB infection has been found to be more pronounced in this part of the world. As
described previously, CHB infection has two phases with HBeAg positive and HBeAg negative based on ALT, DNA & biopsy.
The latter was previously described to have a benign course. The later guidelines have distinguished HBeAg negative status into
two categories with an inactive phase and a reactivation one. In this review article we have highlighted HBeAg Negative status
burden in South Asian countries and shown that HBeAg negative CHB infection may not be as benign as previously thought.
Furthermore , mutations at precore and basal core promoter region may contribute to disease severity in HBeAg negative CHB
infection.

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Published

2020-10-23

How to Cite

Shrestha, A., Lama, T. K., KC, S., Sharma, D., Khadka, S., Dhakal, G. P., & Gupta, B. P. (2020). HBeAg negative chronic hepatitis B in South Asia. Bhutan Health Journal, 2(2), 16-22. https://doi.org/10.47811/YVJF8639

Issue

Section

Review Article